Every man reaches a moment when he wants to settle down and have a loving family. But not Henry—he was convinced he would stay single forever, believing it was the better life for him. However, a day with his nine-year-old niece makes him realize the true reason behind his choices.
The morning light filtered through unfamiliar curtains, and I woke up to the sensation of something warm and wet on my face.
It was a dog—not mine—a small, fluffy creature with wide, eager eyes that seemed to say, You’re mine now.
It licked my cheek persistently, wagging its tail with determination. Did it want food? A walk? Who knew?
As I rubbed my eyes, the events of the previous night slowly returned. I turned my head and saw her—a girl I’d met at the club.
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She was asleep, her hair sprawled across the pillow.
This wasn’t my place. If I was here, that meant I’d accomplished what I’d set out for.
And now it was time to do what I always did: gather my things and make a quiet exit.
I slipped out of bed carefully, scanning the room. There were my pants, crumpled on the floor. My shirt hung awkwardly off a chair.
One sock sat beside my shoe, but the other… where was it? My search led me to the dog’s mat.
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There it was, claimed by the little fluffball now wagging its tail with pride.
I crouched down, whispering,
“Hey, buddy, that’s mine.” I reached for the sock, but the dog grabbed it with its teeth, growling playfully.
Just as we began our tug-of-war, a groggy voice broke the silence.“Henry? Are you up already?”
I froze. She was awake. Turning, I saw her smiling at me with sleepy eyes.
“Uh, yeah,” I stammered, “I’ve got work. Running late for a meeting.”She frowned.
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“But it’s Saturday…”
“I work weekends sometimes. Important stuff, you know.”
Her smile faded, replaced by a curious tilt of her head.
“So… will I see you again?”
“Of course,” I lied smoothly. “I’ll call you.”Her brow furrowed.
“You’ll call me? Did I even give you my number?”
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Uh-oh. Panic swirled in my chest.
“I thought you did. Didn’t you?”
“And how did you save my name?” she pressed.
Caught, I stammered, “By your name, obviously.”
Her gaze sharpened.
“And what’s my name?”
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I swallowed hard. Two options: admit the truth or …
“Nancy?” I guessed weakly.
Her face darkened instantly.
“Get out of here! I knew it! You’re just like the rest—ugh!”
Slippers flew in my direction as I grabbed my jacket and shoes, dodging her fury all the way out the door.
Sitting in my car, I leaned back and sighed. The rearview mirror reflected a face that looked satisfied, smug even.
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This was my life: no strings, no responsibilities, just freedom. Who needed the hassle of a family? Not me.
While others tied themselves down, I lived for the thrill—parties, work, and the kind of independence most people only dreamed about.
A loud ringtone interrupted my thoughts. I glanced at the screen and blinked. Riley? My sister hardly ever called. I hesitated before answering.
“Hello, Riley?”
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“Henry,” she said, her voice tight, “I need to talk to you. Got a minute?”
I frowned. “Sure. What’s going on?”
“Come over as soon as you can. I can’t explain over the phone. When can you get here?”
“Fifteen minutes. Is everything okay?”
“Just come. I’ll explain.”
I stared at the phone for a moment, then started the car. Whatever this was, it had to be serious.
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Twenty minutes later, I pulled into her driveway and barely made it to the door before it swung open.
Riley stood there, arms crossed, her expression a mix of annoyance and urgency.
“You’re late!”
“By five minutes,” I retorted, stepping inside.
“Relax, Riley. You don’t have to be such a pain in the…”
“Don’t swear,” she hissed. “My daughter’s nearby.”
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I followed her gaze and saw Mira, her nine-year-old, curled up on the couch with an encyclopedia.
Her tiny face was scrunched up in concentration, her finger tracing the lines of text like a mini scholar.
“As expected, you’re my last option,” Riley said with a sigh. “I need you to watch Mira today.”
“Me? Are you serious?” I asked, glancing nervously at Mira, who hadn’t looked up from her book.
“I wouldn’t ask if I had another choice,” she said, exasperated.
“I have a business dinner tonight. Either I go and close this deal, or I cancel because I can’t leave her alone. Can you help me or not?”
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“Fine,” I muttered. “If it’s that important.”
“Great. Food’s in the kitchen. I left money in case you need to order something, but keep it healthy. No greasy junk. And she’s not allowed outside. Got it?”
“Got it.”
With a quick goodbye, Riley was out the door, leaving me and Mira alone. I looked at her. She looked at me.
Neither of us said a word. Let the longest day of my life begin.
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The day dragged on like an endless loop of boredom.
Mira sat on the couch, clutching her encyclopedia, and occasionally glanced at me with a look that made me feel like a failing science experiment.
Her small face was calm, but her raised eyebrows screamed judgment.
I cleared my throat.
“So, uh, you like reading?” I asked, trying to break the awkward silence.
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“Yes, I do. Mom says books are knowledge, and I want to know a lot,” she said, her voice cool and sharp, like a character straight out of a movie about child prodigies.
I nodded. “Cool, cool… What’s your favorite subject in school?”
Mira sighed, looking at me as if I’d just asked the world’s most boring question.
“That’s such an unoriginal question, but I’ll answer anyway. I like biology because it has lots of animals, and I love learning about them.”
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“Cool,” I mumbled, unsure what else to say. Conversations with kids were harder than I thought.
After a moment, she closed her book and tilted her head. “So, are you my uncle?”
“Yeah,” I replied. “You probably don’t remember me, though. We met when you were little.”
“Got it,” she said simply. Then she hit me with a curveball. “Are you married?”
“Uh, no. I’m not married.”
“Why not?” she asked, her curious tone sounding more like an interrogation.
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“I don’t want to get married. I like being on my own,” I said, hoping that would end the conversation.
“No one likes being alone,” she replied, crossing her arms.
“I do,” I insisted, though her words stung more than I cared to admit.
“Maybe you’re scared,” she said matter-of-factly.
“Scared? What would I be scared of?”
“Mom says marriage is a lot of work. She also says you don’t like working. So maybe you’re scared of hard work.”
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I sat up straight.
“She told you that!? Well, just so you know, I’m not scared! Maybe it’s just… not for me. For now.”
“Got it. You’re scared,” Mira concluded, her lips curling into a tiny smirk. “Anyway, I’m hungry.”
“Then eat something,” I said, gesturing toward the kitchen.
“Mom said you’re taking care of me. So take care of me,” she shot back.
“Fine,” I muttered, opening the fridge. It was full of salads, juices, and not a single thing I wanted to eat. I sighed and pulled out my phone.
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“Pizza it is,” I declared.
Minutes later, we were sitting on the couch, devouring slices while watching TV. Mira was quiet for once, her face lit up by the screen.
Before I knew it, my head rested against the back of the couch, and the exhaustion of the day caught up with me. I didn’t even notice when I drifted off to sleep.
I woke up with a jolt, blinking against the light streaming into the room. Something felt off. The house was too quiet. I glanced around, and that’s when it hit me—Mira was nowhere to be seen.
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“Mira!” I called out, my voice echoing through the house. “Mira, where are you?”
No answer.
Panic surged through me. I started tearing through the house, opening doors, peeking under beds, and even checking the closets and cupboards.
Every empty space mocked me. My heart raced faster with each passing second.
I had one job. One simple job. Watch Mira for a day, and I couldn’t even manage that.
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I pulled out my phone, desperate for a clue, and saw a text from Riley:
“On my way home. I’ll be there in an hour. Everything okay?”
I froze for a moment, then typed back: “All good!” It was a lie, but I needed time to fix this.
Running downstairs, I scanned the living room again and noticed something I’d missed earlier: the window.
It was open, and a faint breeze fluttered the curtains. Mira had gone outside.
I crawled through the window and spotted a small shoe lying by the neighbor’s fence. My breath caught.
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Climbing over, I found myself in their backyard, where a tall tree stood with a sturdy wooden treehouse perched near the top.
“Mira!” I yelled, looking up.
“I’m here,” her calm voice replied from above.
I climbed the rickety ladder, my pulse still hammering. At the top, I found Mira sitting cross-legged with another boy.
They were playing with toy figures, completely unbothered.
“Mira! You scared me!” I said, still catching my breath. “Why did you run off like that?”
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“I got bored,” she said, shrugging. “And Sam was here. Sam, say hi to my uncle.”
“Hi, Mira’s uncle,” Sam said, not looking up.
“But your mom said you weren’t allowed outside!”
“She said you were supposed to make sure I didn’t go out,” Mira pointed out, her tone matter-of-fact. “But you were sleeping. Now I know what you’re scared of.”
“Of course I was scared!” I snapped, then softened. “Sorry. But why doesn’t your mom let you play with other kids?”
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“She says I’ll pick up bad habits,” Mira said.
“But I like playing with Sam.”
“There’s nothing wrong with playing with other kids,” I said gently.
“Your mom’s just… protective.”
“And you’re not protective enough,” she quipped with a smirk.
I sighed. “You’re right. From now on, I’ll be more careful.”
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In half an hour, the door creaked open, and Riley stepped into the house, her keys jingling as she set them on the counter. “Mira!? Henry!? Where are you two!?” she called out, her voice bouncing off the walls.
No answer.
The house was dark and eerily silent, with no sign of life. The faint glow of the streetlights seeped through the curtains, casting long shadows that made the empty space feel even more unsettling.
Riley’s heart raced as she scanned the room. “Where are they?” she muttered under her breath, her hands trembling slightly. Her eyes darted to an open window, the curtain flapping lazily in the breeze.
“Oh my god! I knew I shouldn’t have trusted my idiot brother!” she mumbled, panic setting in. She rushed toward the window, her mind racing with worst-case scenarios.
Suddenly—
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“Surprise!!” Mira and I popped up from outside, shouting in unison.
Riley jumped back, clutching her chest. “God! I thought you were both gone! What’s wrong with you two!?”
We burst out laughing, and Mira nearly doubled over with glee. Riley’s face softened as she watched her daughter giggling, her playful spirit infectious.
“Sorry, sis. You were asking for it,” I teased, grinning. “Don’t worry so much. Nothing could go wrong, you’ve got to trust Mira a lot more.”
“Yeah, Mom!” Mira chimed in, beaming.
Riley sighed, a reluctant smile creeping onto her face. “You two are impossible,” she said, pulling Mira into a hug. “But I guess I’ll let it slide this time.”
As I left, I realized something: sometimes, kids teach you things about yourself you didn’t even know you needed to learn.
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If you enjoyed this story, read this one: Laura believed that her writing could change the world. But reality turned out differently, and her boss pushed her to dig up dirt on famous people. Desperate to save her job, she disguises herself as a cleaner compromising a millionaire. However, she uncovers a life-changing truth in the process.
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We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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