The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Keanu Reeves’ Shocking Injury on Set: You Won’t Believe What Happened!
Keanu Reeves is a much-loved celebrity, and everyone who’s met him has great things to say about him. So when he recently shared some bad news about himself, many people were worried.
Here’s what happened:
Keanu has been busy working on his new project, *Good Fortune*. He appeared on *The Late Show with Stephen Colbert* this week and shared a story that got people concerned.
The 59-year-old actor revealed that he broke his kneecap while filming. Known for his action roles in movies like *The Matrix* and the *John Wick* series, he explained that the injury came from something surprisingly minor.
Colbert asked, “What happened? Who got to you?”
The actor replied playfully in a tough guy voice, “No one got to me,” adding, “Accident got to me.”
“Were you jumping from building to building? Were you doing a cartwheel past razor blades? What were you doing?” Stephen further probed.
“No, Stephen, I was walking into the dressing room, a room. I will tell it quick,” Keanu explained.
Keanu explained that his injury happened while filming a comedy called *Good Fortune* with Aziz Ansari and Seth Rogen. The three were in a cold plunge, and Keanu was having a good time. Afterward, he was doing a “cold shuffle” in a room with soft carpets when his foot got stuck in a pocket.
To show what happened, Keanu walked in front of Stephen Colbert’s desk and demonstrated how his knee gave way. He described it as if his knee “spiked” into the ground.
He said his kneecap cracked like a potato chip, although he didn’t realize it at first. It wasn’t until his knee started swelling up that he knew something was seriously wrong.
“Comedy is hard, man,” Keanu added as a joke.
“This was not an action film with Aziz and Rogen,” Stephen clarified once again.
“No, it was comedy,” Keanu confirmed.
“Welcome to my life,” Stephen joked.
In January, Keanu was seen filming with crutches and an ice pack on his knee.
*Good Fortune* not only stars Aziz Ansari but is also his first time directing. He wrote and co-produced the movie, which also features Sandra Oh and Keke Palmer.
It’s great to hear that Keanu Reeves has recovered well. Feel free to share this update with anyone who wants to know how he’s doing!
Leave a Reply