The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
I Found a Christmas Gift in My Husband’s Closet, but It Had His Mistress’s Name on It – So I Switched It to Get Revenge
Finding a hidden Christmas gift is supposed to bring excitement and joy — but what if the tag reveals a name that shatters your trust? One woman’s discovery turned heartbreak into a bold act of revenge that’s equal parts shocking and satisfying.
Two days before Christmas, I found a hidden gift box in my husband’s closet meant for his mistress. I didn’t cry. I didn’t scream. I planned the “perfect” surprise instead, one they’d never forget.
I never thought I’d be the type of woman who’d get creative with payback, but life has a way of surprising you. Just like finding that little red gift box in my husband’s closet surprised me. Now, sitting here with a glass of wine, I can’t help but smile at how perfectly my Christmas surprise turned out.
An upset woman | Source: Midjourney
The first sign something was wrong came a month before Christmas. Jimmy started working late… really late. The kind of late that makes you wonder if your husband’s office actually has a bed hidden somewhere.
Then, one day, out of the blue, he was already home. Weird.
“Hey, you’re home early! I took half a day off today. Headache. So, how was the meeting with the client” his voice echoed from the kitchen as I walked through our front door at 7 p.m. These days, that counts as early.
I dropped my keys in the ceramic bowl we’d bought on our honeymoon. “Yeah, the meeting was fine.”
A man smiling | Source: Midjourney
The house felt empty despite the Christmas decorations I’d put up — the garland along the stairs, the wreaths on every door, and the giant tree in our living room that I’d decorated alone while Jimmy worked another late night.
“I made pasta,” he called out. “Want some?”
“Already ate.” I headed upstairs, my footsteps heavy on the wooden stairs. “Got a headache. Think I’ll turn in early.”
A woman ascending upstairs | Source: Midjourney
That night, I lay awake listening to Jimmy’s steady breathing beside me, wondering when exactly we’d become strangers who shared a bed. Five years of marriage, no kids yet. We’d been “waiting for the right time.”
Now, I wondered if there’d ever be one.
My mom had warned me about marrying young. “You’re only 23, Alina,” she’d said. “What’s the rush?”
But I’d been so sure. Jimmy was different. He was special. He was… well, currently getting a text at 2 a.m. that made his phone light up the darkness of our bedroom.
A man using a smartphone in his bedroom | Source: Midjourney
Two days before Christmas, I finally tackled Jimmy’s disaster of a home office and then started cleaning his closet. Between the messy clothes, tangled charging cables, and abandoned gym gear, something caught my eye.
It was a red gift box tucked behind some of his winter coats.
My heart skipped. Maybe I’d been wrong. Maybe he’d planned a surprise. Maybe all those late nights were just him working hard to afford something special for me.
Then I saw the note attached with a pristine silver ribbon: “LOVE YOU, JULIE!”
Here’s the heartbreaker: My name IS NOT JULIE!
A red gift box | Source: Midjourney
The world didn’t stop spinning. My hands didn’t shake. Instead, a strange calm washed over me as I opened the box to find a diamond necklace — the exact one I’d shown him months ago during our anniversary dinner.
“Look how beautiful that is,” I’d said, pointing to the jewelry store window.
“Too expensive,” he’d replied, barely glancing up from his phone.
Apparently not too expensive for Julie, though!
A heartbroken woman holding a red gift box | Source: Midjourney
I pulled out my phone and dialed Mark, my furniture-fixing friend from college. “Remember when you said you owe me for helping with your divorce paperwork? Time to cash in that favor.”
“Alina? Everything okay?”
“Not really. How good are you at modifying gift boxes?”
Mark’s workshop smelled like sawdust and revenge when I visited. He whistled as he examined the box. “You sure about this, Alina? Once we modify it, we can’t—”
“Absolutely.” I handed him a small canister that contained my secret recipe for revenge. “Make it count.”
A woman holding a small canister | Source: Midjourney
“It’ll trigger the moment anyone lifts the lid more than an inch.” He demonstrated the mechanism with careful hands. “Spring-loaded, just like you asked. It will hit everything within a three-foot radius. Industrial grade stuff.”
I smiled, imagining the scene. “Perfect!”
“Want to tell me who it’s for?”
“Let’s just say someone’s getting an extra special Christmas surprise this year.”
A woman smiling | Source: Midjourney
That evening, I returned the gift box to its hiding spot, right where Jimmy would expect to find it. Now came the hard part… waiting.
Christmas morning dawned bright and cold. I’d always loved the magic, anticipation, and joy of Christmas. This year, I felt a different kind of anticipation as I watched from the kitchen while Jimmy grabbed his coat, the red box poorly hidden under his arm.
“Heading to the office, hun?” I asked sweetly, stirring my coffee. “On Christmas?”
A man smiling against the backdrop of Christmas decorations | Source: Midjourney
“Just for an hour,” he mumbled, not meeting my eyes. “Emergency client meeting, sugar.”
“Of course. Don’t work too hard.”
He smiled and left. I grabbed my car keys and followed him to Honey Bunz, our favorite restaurant.
Through the window, I saw her. JULIE. My husband’s mistress. She had that perfectly styled blonde hair, red lipstick, and a designer outfit. Everything I didn’t have.
A young woman smiling in a restaurant | Source: Midjourney
Julie bounced in her seat like a kid on Christmas morning as Jimmy approached. “Awww, Jim, darling! You shouldn’t have!” She clapped her hands together, drawing stares from nearby tables.
“Anything for you, sweetheart.” Jimmy’s voice carried through the window he’d forgotten to close completely. He slid into the booth across from her, presenting the glittery box with a flourish. “I picked it out for you, my love.”
“Oh my god, is it…?” Julie’s eyes widened as she grabbed the box. “The diamond necklace from La Enchanted Diamonds? The one I showed you last month? The diamond ring from Botswana?”
An excited woman holding a glittery gift box | Source: Midjourney
“Open it and see, sugar.” Jimmy leaned forward, grinning like a fool.
“I’m trying. The knot seems a bit too tight,” Julie said.
“Let me help you,” Jimmy rose from his chair and approached her as they untied the ribbon.
“Three…” I whispered, my phone steady and recording. “Two… one…”
SPLAT!
The explosion of green paint was magnificent. Julie’s scream hit a note I didn’t think was humanly possible. “MY HAIR! MY DRESS!” She jumped up, paint dripping down her face like melted ice cream. “JIMMY, WHAT THE HELL IS THIS?”
A startled woman shrieking | Source: Midjourney
Jimmy stood frozen, mouth open, green paint dripping from his nose. “I… I don’t…”
“Is this some kind of joke?” Julie shrieked, wiping paint from her eyes. “Do you think this is funny, you MORON?”
An elderly woman at the next table snorted into her mimosa. “Well, I think it’s hilarious!”
“Someone get this on video!” a teenage boy called out.
“Already trending!” another responded, typing furiously on his phone.
A shocked man with his face covered in green paint | Source: Midjourney
Julie grabbed her ruined designer purse. “I look like the Grinch threw up on me! This dress cost more than your monthly salary, you idiot!”
“Julie, baby, wait—” Jimmy stood up, spreading green paint everywhere.
“Don’t ‘baby’ me! I’m done being your dirty little suprise!” She stormed toward the door, leaving green footprints in her wake. “And by the way? Your wife’s way too good for you!”
You got that right, sister!
A furious woman | Source: Midjourney
I barely made it home before Jimmy burst through the door, his face and expensive suit covered in bright green paint.
“What happened to you?” I gasped, fighting to keep my expression concerned. “You look like the Grinch!”
“Some… some kids with paint balloons,” he sputtered. “They were targeting everyone outside my office.”
“On Christmas? How awful!” I reached for the manila envelope on the counter. “Oh, by the way, these came for you today. Consider it my Christmas gift, DARLING!”
A woman holding a manila envelope | Source: Midjourney
Jimmy’s paint-streaked fingers trembled as he opened the envelope. His eyes widened at the divorce papers inside.
“WHAT?” He looked up, anxiety dawning on his green face.
“Merry Christmas, darling.” I pulled the diamond necklace out of my pocket. “By the way, your taste in jewelry has improved since our anniversary. Poor Julie. She missed out on this!”
A woman holding a diamond necklace | Source: Midjourney
“You… you swi—”
“Yep! I switched the gift box you’d so lovingly hidden for your sweet mistress! How was the surprise? Liked it?”
“Alina, honey, let me explain. You don’t understand!” He stepped forward. “Julie means nothing to me! She was a mistake!”
“A mistake?” I laughed. “A mistake is forgetting to buy milk. A mistake is mixing whites with colors in the laundry. Buying your mistress the exact necklace your wife wanted? That’s betrayal.”
A man gaping in shock | Source: Midjourney
“We can fix this!” He reached for me with paint-stained hands. “I’ll do anything! Counseling, therapy, whatever you want!”
“What I want?” I stepped back. “I wanted a faithful husband. I wanted the man I married. Instead, I got a liar who can’t even come up with a decent excuse for being caught. ‘Kids with paint balloons?’ Really?”
“Baby, please,” Jimmy stepped forward, green paint dripping onto our pristine floors. “It was nothing serious. Julie was just… she didn’t mean anything. We never—”
“Save it.” I held up my hand. “I’ve heard all the excuses. ‘She’s just a friend.’ ‘We’re just colleagues.’ ‘Those late nights were just work.’ Do you know what the worst part is? I actually believed you for a while.”
An angry woman yelling | Source: Midjourney
“Don’t do this. Please. I’m sorry.”
I laughed. “You know what’s funny? I spent months thinking I wasn’t enough. That I needed to be prettier, smarter, and better somehow. But standing here looking at you covered in paint, I realize you’re the one who was never enough.”
“Give me another chance.”
“No.” I grabbed my packed suitcase from behind the couch. “But thanks for the necklace. Consider it my consolation prize. Oh, and Jimmy? Green really isn’t your color.”
As I drove away, I caught one last glimpse of Jimmy in my rearview mirror, a pathetic green figure standing in our driveway. My phone buzzed with notifications. Apparently, someone had posted the paint incident online. The video was already going viral.
A woman driving a car | Source: Unsplash
The last I heard, Julie dumped him following the paint incident that made rounds at the law firm where they worked. She couldn’t handle being known as ‘the green mistress.
Jimmy tried dating apps for a while, but it’s hard to find matches when you’re infamous as “the green Christmas cheater.”
Me? I’m doing just fine. The necklace looks beautiful with everything I wear. Every time it catches the light, I smile, remembering my special Christmas payback: the day I wrapped up my marriage with a bow and a whole lot of green paint.
A cheerful woman wearing a diamond necklace | Source: Midjourney
Here’s another story: I mourned my dead wife for 23 years after she died in a plane crash. But fate had arranged for one more meeting with her.
This work is inspired by real events and people, but it has been fictionalized for creative purposes. Names, characters, and details have been changed to protect privacy and enhance the narrative. Any resemblance to actual persons, living or dead, or actual events is purely coincidental and not intended by the author.
The author and publisher make no claims to the accuracy of events or the portrayal of characters and are not liable for any misinterpretation. This story is provided “as is,” and any opinions expressed are those of the characters and do not reflect the views of the author or publisher.
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