Paris Jackson, born April 3, 1998 in Beverly Hills, California, is much more than the daughter of the legendary Michael Jackson. Her memoir illustrates her development into a well-rounded artist and committed advocate for important causes.
From a young age, Paris showed great interest in various artistic fields, including music, acting and modeling. Her distinctive looks quickly brought her into the fashion world, where she made a name for herself as a successful model.
At the same time, she explored her musical talents by co-founding the folk-rock band The Soundflowers, showcasing her skills in both singing and songwriting. Acting also became an important part of her career, with notable roles in television shows such as “Star” and various film projects.
Beyond her artistic achievements, Paris is a passionate advocate for mental health and LGBTQ+ rights. She has spoken openly about her own mental health issues, contributing to the conversation and reducing the stigma surrounding these issues.
Paris uses her platform to support organizations focused on mental health support, addiction recovery and suicide prevention, underscoring her commitment to driving positive social change.
In a recent episode of her Facebook Watch series “Unfiltered,” Paris introduced her “eldest brother” Omer Bhatti, revealing a deep and previously unknown connection. Omer, a Norwegian dancer and rapper, sees himself as a sibling figure to the Jackson children and has a particularly close bond with Paris.
Omer’s insights into the Jackson family provide a unique perspective on their personal development and dynamics. His role as mentor and confidant reflects the supportive influence Paris’ father had on him. Their relationship has evolved over time, providing mutual support and comfort.
These select family dynamics within the Jackson circle highlight the importance of relationships based on shared experiences and unconditional love.
Paris Jackson’s journey is extraordinary, not only as a versatile artist, but also as a staunch advocate for social progress and mental health awareness. Proving that she is more than just her famous lineage, she has become a powerful force for change and a beacon of inspiration for many.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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