The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Kevin Bacon and Wife Find True Happiness After Losing Fortune and Moving to a Farm!
When we think of strong, loving Hollywood couples, Kevin Bacon and Kyra Sedgwick come to mind.
They have been married for over 30 years, celebrating their 35th anniversary this year with a sweet throwback photo on social media.
Despite their long careers in the entertainment industry, there was a time when they lost millions…
In 2009, their lives turned upside down when they got caught in Bernie Madoff’s infamous Ponzi scheme, which was the largest in history. This scam cost them up to $30 million, as estimated by StyleCaster. Bacon mentioned on the SmartLess podcast that they lost “most of our money.”
They were just two of many celebrities and high-profile figures who were scammed by Madoff’s “too good to be true” financial schemes.
“There are obvious life lessons here. If something seems too good to be true, it probably is,” Bacon told hosts Jason Bateman, Will Arnett, and Sean Hayes. “When something like that happens, you look at each other and say, ‘Well, that sucks. Let’s roll up our sleeves and get to work.’”
Despite the setback, 65-year-old Bacon and 58-year-old Sedgwick used the adversity as an opportunity to reflect and focus on the positives. “We’ve made it this far, our kids are healthy, we’re healthy. Let’s look at what we have that’s good,” Bacon said on the October 2022 podcast.
Bacon and Sedgwick decided to step away from the spotlight and Hollywood, finding peace and happiness on a cozy farm in Connecticut.
Over time, they shared glimpses of their daily lives on social media. Sedgwick posted so many videos of her and their goats on TikTok that people now recognize her more for that than her acting roles!
“People say, ‘We love you singing with the goats.’ Kevin and I are like, ‘Great, but have you seen our movies or TV shows?’ But it makes people happy,” the actress and producer told People in March this year.
Interestingly, Bacon and Sedgwick aren’t the only celebs drawn to farm life. In fact, famed actress Jennifer Garner decided to buy back the farm her mother grew up on and transform it into an organic produce project for baby food.
What do you think of celebs gravitating towards farm life? Do you think it would be a nice break from the fast-paced Hollywood experience? Let us know in the comments!
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